Sexual Dysfunction: Overview of Neurological Diseases and Depression

  • Nasrin Abolhasanpour Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Amirreza Naseri Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sakineh Hajebrahimi Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran; Urology Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Leila Vahedi Liver and gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Fatemeh Rahmati Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hanieh Salehi-pourmehr Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Sexual expression is dependent on physiological and psychological systems, and it is one of the most complex aspects of human life. Neurological disorders can alter the processing of sexual stimuli. Previous studies investigated that up to 85% of women with MS, 43% of PD or other neurological diseases have a degree of sexual dysfunction (SD). The release of neurotransmitters such as glycine, GABA, glutamate, serotonin, and norepinephrine levels may have altered in various neurological diseases. Furthermore, many physical complications of neurological disorders and several psychological disorders such as depression are common in these patients. The current evidence showed that 40% of SCI patients experience depression after the injury. Depression is a serious and debilitating disorder and has various negative consequences for physical health and sexual function.

Moreover, the involvement of neurotransmitters in several different body's functions has an impact on sexual behaviour in both sexes. Serotonin has a critical role in sexual activity. Also, depression is a direct risk factor for worsening SD. This review discusses the SD in patients with neurological disorders like SCI, PD, Cognitive impairments, and MS, with an especial focus on depression-induced SD. 

Keywords: Sexual dysfunction, Neurological diseases, Depression

Published
2020-05-25
Section
Review Article