A Review on the Role of MicroRNAs in Ischemic Stroke Recovery

  • Leila Hosseini Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Deptartment of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Manouchehr S Vafaee Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Psychiatry Research Unit, Southern Denmark Region, Odense, Denmark; Department of Nuclear Medicine, Odense University Hospital, Odense Denmark.
  • Fereshteh Farajdokht Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Deptartment of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Javad Mahmoudi Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Ischemic stroke has become one of the primary causes of morbidity and mortality in the world. MicroRNAs (miRNAs), small ribonucleic acids (RNAs), negatively regulate gene expression on the post-transcriptional level via promoting degradation or translational inhibition of their target mRNAs. Recent studies have shown that miRNAs have been implicated in the pathophysiological processes contributing to ischemia-reperfusion injuries and could serve as critical mediators of recovery following ischemic stroke. This review summarizes emerging studies that show cerebral miRNAs regulate blood-brain barrier (BBB) function, apoptosis, inflammation, and oxidative stress in stroke.  It has been demonstrated that the regulation of miRNAs expression may be a novel therapeutic target in ischemic stroke recovery.

Keywords: Ischemic stroke, MicroRNA, Oxidative stress, Inflammation, Blood-Brain Barrier, Apoptosis

Published
2020-12-12
Section
Mini Review Article