Difference between Plasma Concentrations of Three Amino Acids in Patients with Ischemic and Hemorrhagic Stroke

  • Hormoz Ayromlou Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sara Khoshsoroor Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Hamed Ghavimi Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  • Siminozar Mashayekhi Applied Drug Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammadreza Sattari Neurosciences Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Hematology and Oncology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Objectve: Taurine, glycine and glutamate are the most abundant amino acids in the body and their plasma concentratons may affect by ischemic or hemorrhagic stroke.


Materials and Methods: In the present study, the plasma concentratons of taurine, glutamate and glycine in the 120 patents suffering from stroke (60 ischemic and 60 hemorrhagic) were determined using an already developed HPLC method with fluorescence detecton and were compared with the result of 60 healthy volunteers. The plasma samples of the patents were obtained three tmes in the frst fve days of hospitalizaton.


Results: A one-way ANOVA test showed a signifcant difference between the plasma concentraton of taurine in the ischemic, hemorrhagic, and control groups (p<0.0001). However, plasma concentratons of glycine and glutamate had no signifcant difference in both groups (p>0.05).


Conclusion: We showed that the plasma concentraton of taurine increases in the patents with stroke probably because of brain tssue damage which is not a simple release of all contents of cells because glycine and glutamate did not have signifcant changes.

Published
2018-01-07
Section
Original Article