Effects of Acute and Chronic Noise Stress on Depressive- and Anxiety-like Behaviors in Mice

Farzad Salehpour, Javad Mahmoudi, Nazila Eyvazzadeh

Abstract


Objective: Noise is an inescapable stressor of modern life and a substantal number of populaton are exposed to noise produced by urban trafc, air crafs, and the industrial environment. The noise stress causes central nervous system dysfuncton and altered brain neurotransmission and hormone levels that potentally result in psychological and behavioral changes. In this study, we investgated the impact of acute and chronic noise stress at levels of 90 and 110 dB on different behavioral tasks.

Materials and Methods: Sixty male BALB/c mice were randomly divided into 6 groups: control-acute, acute-noise 90 dB, acute-noise 110 dB, control-chronic, chronic-noise 90 dB, and chronic-noise 110 dB groups. Mice in acute- and chronic-noise groups were exposed to 2 h/day of 90 or 110 dB white noise for 1 day and 12 weeks, respectvely. In order to evaluate depressive- and anxiety-like behaviors mice were subjected to tail suspension and elevated pulse maze tests, while locomotor actvity was assessed by the open feld test.

Results: In this study, acute and chronic noise at 90 and 110 dB increased depressive-like behavior. The acute noise at 110 dB and chronic noises at both 90 and 110 dB induced anxiety-like behaviors. Moreover, a signifcant reducton in locomotor actvity in open feld test was observed following acute 110 dB and chronic 90 and 110 dB noises.

Conclusion: In summary, the current study shows that noise stress at levels above 90 dB causes short- and long-term behavioral changes including depressive and anxiety-like symptoms as well as low locomotor actvity.


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DOI: http://dx.doi.org/10.13183/jecns.v5i1.73

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