Evaluation of Mesenchymal Stem Cells and Granulocyte Colony Stimulating Factor in Treatment of Complete Spinal Cord Injury

  • Mohammadreza Emamhadi Brachial Plexus and Peripheral Nerve Injury Center, Guilan University of Medical Sciences, Rasht, Iran
  • Bahram Soltani Cellular and Molecular Research Center, Guilan University of Medical Science, Rasht, Iran
  • Shahrokh Yousefzadeh-Chabok Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran
  • Parvin Babaee Cellular and Molecular Research Center, Guilan University of Medical Science, Rasht, Iran
  • Hamid Behzadnia Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran
  • Shervin Ghadarjani Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran
  • Sasan Andalib Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran http://orcid.org/0000-0003-0904-0925

Abstract

Objectve: Spinal cord injury (SCI) mostly affects the young and has no defnite treatment. There is a growing body of literature showing the efcacy of stem cells or growth factors in the treatment of partal SCI, but a few studies demonstrated complete SCI recovery. Thus, the aim of the present study was to assess the efcacy of Mesenchymal Stem Cells (MSCs) or Granulocyte Colony Stmulatng Factor (GCSF) therapy in the complete SCI recovery.


Material and Methods: 45 Rats were divided into 5 groups (GCSF, MSCs, GCSF + MSCs, control, and sham) and underwent SCI (except the sham group) using aneurysmal clip compression. Each group received its relevant therapy.


Results: Afer inducton of SCI, there was a non-signifcant increasing trend in (Louisville Swim Scale) (LSS) score in all the treated groups, notwithstanding a plateau in the recovery in the sham group. No signifcant difference was found in the locomotor recovery among the groups.


Conclusion: The evidence from the present study indicates that GCSF and MSCs therapy fail to recover SCI.

Published
2018-01-07
Section
Original Article