Evaluation of Mesenchymal Stem Cells and Granulocyte Colony Stimulating Factor in Treatment of Complete Spinal Cord Injury

Mohammadreza Emamhadi, Bahram Soltani, Shahrokh Yousefzadeh-Chabok, Parvin Babaee, Hamid Behzadnia, Shervin Ghadarjani, Sasan Andalib

Abstract


Objectve: Spinal cord injury (SCI) mostly affects the young and has no defnite treatment. There is a growing body of literature showing the efcacy of stem cells or growth factors in the treatment of partal SCI, but a few studies demonstrated complete SCI recovery. Thus, the aim of the present study was to assess the efcacy of Mesenchymal Stem Cells (MSCs) or Granulocyte Colony Stmulatng Factor (GCSF) therapy in the complete SCI recovery.


Material and Methods: 45 Rats were divided into 5 groups (GCSF, MSCs, GCSF + MSCs, control, and sham) and underwent SCI (except the sham group) using aneurysmal clip compression. Each group received its relevant therapy.


Results: Afer inducton of SCI, there was a non-signifcant increasing trend in (Louisville Swim Scale) (LSS) score in all the treated groups, notwithstanding a plateau in the recovery in the sham group. No signifcant difference was found in the locomotor recovery among the groups.


Conclusion: The evidence from the present study indicates that GCSF and MSCs therapy fail to recover SCI.


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DOI: http://dx.doi.org/10.13183/jecns.v5i1.77

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