Cerebrolysin Ameliorates Cisplatin-Induced Neuropathic Pain in Mice: A Behavioral Study

  • Ali Namvaran-Abbas-Abad
  • Ferehsteh Farajdokht
  • Javad Mahmoudi
  • Seyed Mahdi Vatandoust


Objective: Cisplatin (Cis) is a potent chemotherapeutic agent in clinical use which is associated with nephrotoxicity and neuropathic pain possibly through inflammatory response. Cerebrolysin (CBL), a mixture of neurotrophins, has analgesic and anti-inflammatory properties. The aim of the present study was to investigate the effects of cerebrolysin on cisplatin-induced neuropathic pain in mice.

Materials and Methods: Mice were randomly divided into five groups: Control, Cis, Cis +CBL, Cis + vitamin E (Vit E), and Cis + Morphine. CBL and Vit E were injected for 4 consecutive days following single injection of Cis. On day 4 animals were subjected to three behavioral tests including cold plate, hot plate, and formalin tests.

Results: The results showed that mice treated with CBL had higher withdrawal thresholds in the hot plate and cold plate tests as well as displayed lower hyperalgesia-related behaviors in the formalin test as compared to the Cis group. Moreover, CBL induced higher anti-nociceptive effects than Vit E and lesser effects than morphine, in hot plate and cold plate tests. Furthermore, the analgesic effect of CBL was similar to morphine effect in the late phase of formalin test.

Conclusion: Our results indicated that CBL has an anti-nociceptive effect against cisplatin-induced neuropathic pain.

Original Article