Purinergic Signaling in Spinal Cord Injury Induced-Neurogenic Bladder: A Mini- Review Study
Normal micturition (urination) including storage and periodic elimination of urine requires proper function of both the bladder and the urethra and a healthy central nervous system (CNS), which coordinates sympathetic, parasympathetic, and somatic nervous system activity. Any disruption in this pathway leads to the neurogenic bladder (NGB). Adenosine triphosphate (ATP) besides acetylcholine leads to bladder contraction and voiding reflex in many species. The main neurotransmitter of healthy human for initiating muscle contraction is acetylcholine. However, in pathological conditions such as NGB, purinergic components increase and its signaling is introduced as a new pathway. This review discusses the purinergic signaling pathway and its role in NGB following spinal cord injury (SCI).