Antioxidant Aspect of Exercise in Improving Cognitive Function in Alzheimer's Disease

  • Mahnaz Talebi Neurosciences Research Center, Tabriz University of Medical Sciences
  • Neda Ghaemian Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the elderly. Despite the high prevalence of AD, it has no definite treatment. Therefore, many efforts are being made to find non-drug therapies along with medical treatments, particularly in mild cognitive impairment (MCI) and early Alzheimer's disease. One of the non-medical methods that have been investigated in recent years is exercise. Exercise with different mechanisms can affect the disease process and maintain nerve functions. Some of these mechanisms include regulation of neurotransmitter synthesis and increase of acetylcholine, promotion of the synthesis of neuronal growth factors, increase interconnections between synapses, increase cerebral blood flow and thereby accelerate the removal of waste, and enhance blood antioxidant enzyme. In this short study, we investigate the antioxidant aspect of exercise in improving cognitive function in Alzheimer's disease.

Review Article