A Visualized Guideline for Cancer Chemotherapy Induced Neuropathic Pain in Mice Using Cisplatin

Ali Namvaran; Javad Mahmoudi; Saeed Sadigh-Eteghad; Siamak Sandoghchian Shotorbani; Siamak Reyhani-Rad

doi:10.13183/jecns.v2i1.30

Ali Namvaran Young Researchers and Elite club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Javad Mahmoudi Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
Saeed Sadigh-Eteghad Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
Siamak Sandoghchian Shotorbani Department of microbiology, Tabriz branch, Islamic Azad University, Tabriz, Iran
Siamak Reyhani-Rad Department of laboratory sciences, Marand Branch, Islamic Azad University, Marand, Iran

DOI: https://doi.org/10.13183/jecns.v2i1.30

Abstract

Neuropathic pain associated with cancer chemotherapy remains an important source of trouble for different cancer therapy regimens. Cisplatin is a platinum based agent widely prescribed in clinics and induces dose?dependent painful sensory neuropathy; modeling of its toxicity in animal models is, therefore, of interest. Among various species of rodent models, mice are used frequently to reproduce the neuropathic condition. Special considerations are required for using mice in this procedure. Different steps, considerations and approaches including cisplatin intravenous injection as well as behavioral assessment of cisplatin sensory neuropathy are explained in this paper.